Assessment of the Ameliorative Effect of Bacillus subtilis against the Toxicity Induced by Aflatoxin B1 in Rats

Aflatoxin B1 (AFB1) is the most toxic and common among major types of aflatoxins. AFB1 hepatoxic has been implicated in an increase risk hepatocellular carcinoma, also effect AFs on brain chemistry have documented. Probiotics health benefits provide powerful for body brain. The present study was designed to reveal efficiency Bacillus subtilis NS4182-01 against hematological, biochemical histopathological alterations induced by rats. Both B. were studied experimental animals (rats) that divided into 6 groups as following: Group 1 (control) received distilled water orally. Groups 2&3 (B. treated groups) orally at a dose 0.25 0.50 ml, respectively. 4 (AFB1 group) with 2 mg/kg b.w. 5&6 + then two doses It noticed hematological measurements declined elevated significantly (P≤0.05) group. restored all towards normal values. Moreover, native electrophoretic protein patterns showed physiological occurred lipid moiety addition calcium result treatment represented hiding one or more existence abnormal ones. Therefore, similarity index (SI%) genetic distance (GD%) values altered (SI=40.00%; GD=60.00%), (SI=50.00%; GD=50.00%) (SI=75.00%; GD=25.00%) Although ml ameliorative but could not restore state normalcy. While integrity these restoring absent this group became physiologically similar control (SI=100.00%; GD=0.00%). These findings supported results examination target organs (liver, kidney brain) affected their structure maintained architecture organs.